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A recent study indicates that hyperleptinemia may independently predict the prognosis of cardiovascular disease, irrespective of obesity ( In contrast to leptin, circulating APN concentrations are reduced in obese individuals, which is a phenomenon hypothesized to play a pivotal role in the pathogenesis of atherosclerosis and cardiovascular diseases associated with obesity and the metabolic syndrome ( In patients with PCOS, there is a significant increase in serum leptin and a corresponding decrease in APN levels ( Expanding beyond classical adipokines regulation, the therapeutic spectrum of resveratrol encompasses interactions with long non-coding RNAs (LncRNAs) a category of non-coding RNAs with a transcript length exceeding 200 nts, exhibiting tissue-specific and spatiotemporal-specific expression patterns

A patient who started surgery with adequate B12 can come through the perioperative period slightly depleted, particularly if appetite was reduced in the early recovery weeks or if there were any complications affecting oral intake

Arevalo, R

Metabolism 74 , 19 (2017)