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Distribution of GLP-1 fibers in the spinal cord We correlated the distribution of GLP-1R-IR neuronal elements with the GLP-1 innervation of the spinal cord that originates primarily, if not exclusively, from lower brainstem neurons 20

On the other hand, GIP is synthesized as a pro-peptide (pro-GIP) that is post-translationally processed to GIP in K-cells