Cytokine suppression: the numbers The specific cytokines reduced by GLP-1 receptor activation read like a hit list of autoimmune mediators: TNF-alpha drives joint destruction in rheumatoid arthritis , skin plaque formation in psoriasis, and intestinal inflammation in Crohn disease
Furthermore, HIF-1 depletion impacted glucose consumption and uptake, as well as glycolytic gene expression in the same setting (Fig
However, we now know that when blood sugar levels get under control, the GIP receptor starts to work more effectively again, and as this is a very strong receptor, there is a good case for developing therapies that target the GLP-1 receptor and the GIP receptor simultaneously
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