This strategy gives your body more time to adapt to changes, reduces the severity of side effects, and improves long-term adherence
Post-cholecystectomy syndrome involves chronic diarrhea, fat intolerance, and bloating after gallbladder removal
This effect is associated with increased insulin signal transduction via phosphatidylinositol-3-OH kinase in the liver (but not in the skeletal muscle) and with reduced hepatic expression of the gluconeogenic genes, glucose-6-phosphatase and phosphoenolpyruvate kinase (German et al., Leptin, insulin, and nutrient-related signals in the CNS improve hepatic insulin sensitivity however, the mechanism by which CNS leptin signaling normalizes diabetic hyperglycemia and whether this process involves leptin-dependent effects on hepatic glucose production or tissue glucose uptake are unknown (German et al., 2011)
[DOI] [PMC free article] [PubMed] [Google Scholar] 12.Llewellyn-Smith I.J., Reimann F., Gribble F.M., Trapp S