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doi: 10.1016/j.phymed.2024.156122 170 HeYZhuYShuiXHuangZLiKLeiW

In addition to oxidative stress, excessive copper ion accumulation alters energy metabolism patterns within cardiomyocytes by inducing abnormal aggregation of thioctylated proteins and loss of iron-sulfur cluster proteins in the respiratory chain complex through direct binding to thioctylated proteins in the mitochondrial TCA cycle (76)

AOD9604, Joint Function, and Cartilage Research Beyond adipose-focused studies, AOD9604 has been examined in experimental models of joint disease and osteoarthritis: In rat models, intra-articular administration of AOD9604 has been explored for its effects on pain-related behavior, joint function, and structural parameters

The mechanism appears to involve modulation of stress response pathways that are hyperactive during withdrawal