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Following a second administration of Donor+Cas9, plasma Exe4 levels increased and remained elevated for over 28 weeks, doubling the level of Exe4 production and secretion compared to a single administration, suggesting the potential for fine-tuning the regimen dose through repetitive administration (Supplementary Fig

You have 4.5mg, plus 0.5mg of unknown substances that could confound your results

Intracellular components are first engulfed in double membrane vesicles called autophagosomes, which subsequently fuse with lysosomes for digestion of their contents and recycling of their building blocks

Virmani MA, Cirulli M