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Chronic deficiencies may require ongoing treatment

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Yet, there was no statistically significant difference between melatonin levels before and after placebo administration [14]

This analogy is important both for conceptualizing the uric acid crystals in the joint and for understanding the various types of gout treatment (see below), some of which attack the inflammation (pour water on the flaming matches) and some of which remove the uric acid crystals (take away the matches)