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The persistent accumulation of ROSarising from endogenous sources (e.g., mitochondrial leakage, enzymatic reactions) and exogenous insults (e.g., ultraviolet radiation, pollutants, tobacco)can overwhelm the antioxidant defense threshold, triggering widespread oxidative damage targeting proteins, lipids, and nucleic acids

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Vaccine sales dragged on 2024 results as shingles, flu and RSV shots fell back versus the prior year, but GSKs other key therapeutic areas, including HIV, respiratory/immunology, oncology and respiratory, grew