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Seek emergency care immediately if you experience dark/brown urine with severe muscle pain, as this may indicate rhabdomyolysis, a serious condition requiring urgent treatment

Direct Meds cites clinical trial data on their website and states that patients may lose 1-2 pounds per week on average under specific trial conditions

Summary: Retatrutide should not be combined with insulin or sulfonylureas without medical supervision, and caution is advised with anticoagulants, narrow therapeutic index drugs, other GLP-1 receptor agonists, and supplements with hypoglycaemic properties

If it has been more than 5 days since your missed dose, skip the dose completely