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In most tissues, cationic amino acids are transported principally by a Na + -independent system, specific for L-isomers of lysine, arginine, and ornithine

Acknowledgements We thank the field workers for their contribution and the participants for their cooperation

Additionally, targeted deletion of Ramp1 specifically in macrophages diminished pain-related behaviors and reduced lesion size and number, confirming the key role of CGRP/RAMP1-mediated nociceptor-to-macrophage communication as a novel avenue for immunotherapy and targeted molecular treatment in endometriosis, addressing both pain and lesion development