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The appetite-suppressing effects of semaglutide allow many patients to achieve a caloric deficit more naturally, while metformin addresses the underlying insulin resistance that often perpetuates weight gain

The dose-response relationship demonstrates that higher doses produce greater reductions in HbA1c and body weight, with clinical effects sustained over long-term treatment (Davies et al., 2021)

Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that begins working shortly after subcutaneous injection, though its full effects develop gradually over several weeks

Most patients can keep taking the drug as usual before their surgery or procedure, but there are things every patient should do to stay safer