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In osteoblasts lacking ER-66, the overexpression of GPER and ER-36 can significantly increase OPG expression, further enhancing bone-protective effects [143]

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368 Compared with AMG-232 monotherapy or chemotherapy alone, therapies involving the combination of AMG-232 and chemotherapies have superior antitumor activity through the promotion of apoptosis and the restoration of p53 activity