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A network meta-analysis published in the Journal of the Endocrine Society found retatrutide achieved 23.77% weight reduction compared to 16.79% for tirzepatide when standardized across trials, with absolute weight loss of 16.34 kg versus 11.82 kg

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While retatrutide is the newest and most potent, reports of emotional flatness have also surfaced among users of approved GLP-1 drugs, such as Mounjaro

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