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The following month, her tirzepatide dose was lowered to 5 mg due to insurance restrictions

Zepbound (tirzepatide) is the first and only FDA-approved obesity treatment that activates both GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) hormone receptors

Moreover, these cells have reduced expression of mitochondrial genes and reduced mitochondrial activity, while glycolysis gene expression and glucose uptake are increased, indicative of metabolic reprogramming