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CoA deficiency is expected to cause substantial abnormalities in cellular metabolism and can potentially explain the additional 9% weight loss in Cse / mice on the no-Cys diet compared to no-Trp + BSO diet (Fig

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[4] [5] Common adverse effects include nausea, vomiting, diarrhoea, constipation, and abdominal pain, particularly during the initial titration phase

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8 Direct action on the skin is a possible mechanism, as GLP-1Rs have been shown to be expressed in the skin of newborn mice and cultured skin cells

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