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55 GLP-1 RAs have demonstrated substantial weight loss effects in clinical trials, with weight reduction typically plateauing after 2060 weeks of treatment, depending on the specific agent

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Use of SEMGLEE for this indication is supported by SEMGLEEs approval as a biosimilar to insulin glargine and evidence from an adequate and well-controlled study (Study D) in 174 insulin glargine-treated pediatric patients aged 6 to 15 years with type 1 diabetes mellitus and from adequate and well-controlled studies of insulin glargine in adults with diabetes mellitus [see Clinical Pharmacology (12.3), Clinical Studies (14.2)]

However, persistent, recurring, worsening, or unusual symptoms should be discussed with the prescribing provider