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(2000) Mitochondrial dysfunction and free radical damage in the Huntington R6/2 transgenic mouse

GSTs are able to conjugate glutathione (-l-glutamyl-l-cysteinyl-glycine, GSH) to a wide range of hydrophobic and electrophilic molecules including many carcinogens, therapeutic drugs, and many products of oxidative metabolism, making them less toxic and predisposed to further modification for discharge from the cell (Fig

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