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Ansamycin derivatives such as 17-AAG (tanespimycin) and 17-DMAG (alvespimycin) reduce tau and -synuclein oligomerization in AD and PD models by promoting their degradation via the ubiquitinproteasome system

By delving into these factors, the review aims to deepen the understanding of the complex interplay of elements that lead to ACL injuries, thereby informing the development of more targeted and effective strategies for the prevention and treatment of these debilitating injuries