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this phenomenon causes mitochondrial dysfunction with increased superoxide radical levels at peak pain, triggering signaling cascades that may underlie the coasting effect, such as apoptosis

High-risk patient factors include active gastrointestinal symptoms (odds ratio 7.66, 95% confidence interval 3.4217.17), early treatment phase (less than 4 weeks), higher medication doses, pre-existing diabetic gastroparesis, obesity (BMI greater than 30), and gastroesophageal reflux disease [31]

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An addiction can interfere with many areas of a persons life, such as their health, relationships, schoolwork, and employment