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Lipodystrophy includes lipohypertrophy (thickening of adipose tissue) and lipoatrophy (thinning of adipose tissue) and may affect insulin absorption [see DOSAGE AND ADMINISTRATION ]

5 These benefits might come from several factors: Weight loss itself improves mood and self-esteem Reduced inflammation (which is linked to depression) Direct effects on GLP-1 receptors in the brain, which are present in areas involved in mood regulation Improved physical function and mobility Healthier eating habits developed while on the medication Evidence suggesting caution is needed However, pharmacovigilance studies (which analyse reports of side effects submitted to drug safety databases) have identified signals for psychiatric adverse events with GLP-1 medications, including semaglutide