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At sacrifice, blood and brain tissues were collected for metabolic, body composition, and transcriptomic analyses

Results from a study examining the safety of using liraglutide in patients with moderate to severe renal impairment demonstrated no deleterious effects on serum creatinine (SCr) or increased incidence or severity of adverse events

On the other hand, and seemingly paradoxically in rats the CB1R agonist WIN 55,212-2 enhanced the anorexigenic effects of subthreshold doses of the GLP1-RA exendin-4 resulting in a significant decrease in food intake and body weight in rats [61]

Our understanding of obesity since the discovery of leptin has revolved around the idea that BMI has a genetic basis, with approximately 4070% of the variation in BMI in the population being attributable to heritable factors [9], and that the majority of genetic variation associated with BMI is in the central nervous system (CNS) [10]