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Additionally, patients with type 2 diabetes who would benefit from weight loss represent ideal candidates, as tirzepatide produces weight reductions of approximately 10-15% of body weight in patients with diabetes (SURMOUNT-2) and 15-21% in patients without diabetes (SURMOUNT-1)

They also provide poor nutritional value relative to their caloric density, which contradicts the treatment goals of improved metabolic health and sustainable weight management as outlined in the NHS Eatwell Guide

Oncotarget 8 , 6567765686 (2017)

The clinical data on AOD-9604 demonstrates remarkable hormonal stability, with no effects on cortisol, thyroid hormones, sex hormones, or the growth hormone/IGF-1 axis