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GLP-1 receptors are expressed in the heart muscle cells, immune system cells in the heart, and in the lining of blood vessels.[ref] GLP-1 RAs have been shown to help in heart failure and also to have beneficial effects on heart rhythm.[ref] Related article : Cardiovascular disease genetic risk factors Cancer Research: Retatrutide, a GLP-1/GIP/GCG triple agonist, has recently been shown to reduce pancreatic tumor mass in animals

So we rolled up our sleeves and dug into the actual science

However, we now know that when blood sugar levels get under control, the GIP receptor starts to work more effectively again, and as this is a very strong receptor, there is a good case for developing therapies that target the GLP-1 receptor and the GIP receptor simultaneously

Acta Neuropsychiatrica, 32 , 218225