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Loss of nigrostriatal dopamine neurons and the following imbalance between anti-kinetic and prokinetic activity contribute to these typical symptoms (Yang et al., 2015)

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Additionally, in the Da Qing Diabetes Prevention Study, a randomized controlled trial in patients with impaired glucose tolerance at baseline, lifestyle interventions in patients with impaired glucose tolerance at baseline reduced the incidence of cardiovascular and all-cause mortality and diabetes incidence, as well as the incidence of diabetes-related microvascular complications (specifically retinopathy) [22, 23]

In the central nervous system (CNS), lutein supports brain homeostasis through its antioxidant and anti-inflammatory properties, increasing interleukin-10 (IL-10) and reducing tumor necrosis factor- (TNF-)