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A large-scale observational study published in 2023 analyzed electronic health records of over 80,000 patients with obesity and found that those prescribed semaglutide had a 50-56% lower risk of alcohol use disorder compared to those on other obesity medications

Such discouraging findings have prompted research efforts directed at the development of small molecules configured to penetrate the blood-brain-barrier (BBB) and stimulate brain neurotrophins

Machine learning algorithms can extract meaningful patterns from high-dimensional biological data, enabling more informed clinical decisions

These factors limit absorption and systemic action [66]