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Systemic injection of MOTS-c can restore the level of MOTS-c in aged mice and successfully reverse age-related skeletal muscle insulin resistance

10.1016/S1473-3099(14)70780-7 Lancet Infect

That is an issue because a dehydrated athlete will have more concentrated urine relative to a well-hydrated athlete, and so the concentration of any substances (prohibited or not) appearing in their urine will be higher, thus increasing the probability of an anti-doping rule violation being pursued against them simply because of their hydration status

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