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Reduced caloric intake and milk supply GLP-1 receptor agonists work by suppressing appetite

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Here we report high-resolution cryo-electron microscopy (cryo-EM) structures of human GLP-1RG s in complex with compound 2 alone, with both compound 2 and endogenous peptidic agonist GLP-1, or with compound 2 and a small molecule agonist (LY3502970)