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Some patients benefit from a lower maintenance dose of semaglutide rather than complete discontinuation, which allows ongoing appetite management at lower cost while preventing the weight-loss plateau effect that can occur with continuous high-dose therapy

semaglutide is global Conclusion# Ecnoglutide's cAMP-biased signaling is a scientifically intriguing approach that could theoretically offer advantages in long-term receptor responsiveness

Biochem J 210:899903 Lelarge-Trouverie C, Cohen M, Trmulot L, Van Breusegem F, Mhamdi A, Noctor G (2023) Metabolite modification in oxidative stress responses: a case study of two defense hormones

The slowed gastric emptying may also reduce oral intake, as patients feel fuller longer and may struggle to consume adequate fluids