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Although these models are inconclusive, there is broad agreement regarding the linear stacking of rod-shaped helical repeat units (Sun et al., 2023)

Test before starting and again at 48 weeks.

The LCMS metabolite peaks were manually integrated and identified using El-Maven (v.0.12.0) by matching with a previously established in-house library 33

Circulating microbes act as messengers within the gutskin axis, primarily via immunological pathways influenced by diet, stress, and environmental factors, which regulate intestinal and skin barrier homeostasis [93, 94].The immune system regulates hostmicrobiota interactions, with microbiota impacting autoimmune and immune-mediated processes via molecular mimicry, bacterial translocation after barrier disruption, modulation of immune cells in Peyers patches, and production of immunomodulatory metabolites [95, 96]