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Glutamatergic transmission is controlled and regulated by astrocytic glutamate-glutamine shuttle, thereby providing a means by which astrocytes may contribute to the pathophysiology of addictive disorders through glutamatergic pathways

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What seems to be the most effective drug treatment now is a combination therapy of both alpha blockers (Hytrin (terazosin), Cardura (doxazosin), Flomax (tamsulosin), Uroxatral (alfuzosin) or Rapaflow (silodosin), which relax the smooth muscle of the prostate and bladder neck, and finasteride (Propecia) or dutasteride (Avodart), also known as 5-Alphareductase Inhibitors (5-ARIs) which can stop growth of the prostate or possibly shrink it

These changes typically peak around week 24 and then abate