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Graphical Abstract Similar content being viewed by others Abbreviations ALD: Alcoholic liver disease ALT: Alanine aminotransferase AST: Aspartate aminotransferase CAT: Catalase GGT: Gamma-glutamyltransferase Glu: Fasting blood glucose GSH-Px: Glutathione peroxidase HDL: High-density lipoprotein HFDs: High-fat diets HOMA-IR: Homeostasis model assessment of insulin resistance IL-1: Interleukin-1 beta IL-6: Interleukin-6 iNOS: Inducible nitric oxide synthase LDL: Low-density lipoprotein MASLD: Metabolic dysfunction-associated steatotic liver disease NF-B: Nuclear factor kappa B SM: Silymarin SM-PNPs: Silymarin-loaded phytosomal nanoparticles SOD: Superoxide dismutase SPC: Soy phosphatidylcholine TC: Total cholesterol TG: Triglycerides TNF-: Tumor necrosis factor-alpha Acknowledgements Authors are thankful to the research assistant staff of Mansoura experimental research center (MERC) for their help and support through the current study

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