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MT-1 in subcutaneous implant formulation and documented significant increases in pain-free sun exposure time in EPP patients, with studies characterising reduced phototoxic reactions, improved quality of life, and clinically meaningful photoprotection in a patient population where even brief visible light exposure produces severe phototoxic pain

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Mice were transcardially perfused, brains were dissected, postfixed, sectioned and stored as previously described 42