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He L, Wang J, Ping F et al (2022) Association of glucagon-like peptide-1 receptor agonist use with risk of gallbladder and biliary diseases: a systematic review and meta-analysis of randomized clinical trials

The TAILGATE study , presented at the European Congress on Obesity in May 2024, offers compelling evidence

These symptoms arise primarily from the medication's mechanism of slowing gastric emptying, which prolongs the presence of stomach contents and increases the opportunity for gastric acid to reflux into the oesophagus

The key principle is that occasional early dosing (24 to 48 hours) is generally tolerable, but regular pattern changes should be discussed with your healthcare provider to ensure you're getting the intended therapeutic benefit