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The researchers discovered that the ratio of mitochondrial calcium (a driver of ROS) to Superoxide Dismutase 2 (an antioxidant enzyme) was highly elevated by 1.75x in ME/CFS and 1.67x in Long COVID compared to healthy controls

Key areas of investigation include: Gastrointestinal : Demonstrated protection against NSAID-induced ulcers, inflammatory bowel disease models, and esophageal damage in multiple animal studies Musculoskeletal : Accelerated healing of transected Achilles tendons, quadriceps muscles, and medial collateral ligaments in rat models Neurological : Neuroprotective effects in models of traumatic brain injury, nerve crush injury, and dopaminergic system damage Organ protection : Hepatoprotective, cardioprotective, and nephroprotective effects demonstrated in various toxicity models The primary limitation is that all evidence comes from animal models

A deficiency in B12 can lead to symptoms of depression, anxiety, and brain fog