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13a, Supplementary Table 9), suggesting that the distinct rotamer orientation of H296 ECL2 in Cagri-bound CTR (to accommodate the Glu linker) and/or the observed more open ECL3 conformation induced by the lipidated peptide may facilitate or stabilize an active CTR conformation (Supplementary Fig

Ann Neurol (2010) 67(4):45261

Whether the differential potency of these conjugated linolenic acids is related to their metabolism by specific enzymes or due to differences in solubility or other physicochemical properties is an important open question