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As the condition worsens, common symptoms include: weakness and fatigue light-headedness and dizziness palpitations and rapid heartbeat shortness of breath a sore tongue that has a red, beefy appearance nausea or poor appetite weight loss diarrhea yellowish tinge to the skin and eyes

Patients with genetic markers indicating higher GLP-1 receptor sensitivity may require lower tirzepatide starting doses or wider injection spacing, whereas those with reduced receptor activity may benefit from faster dose escalation schedules

skin barrier function normalised

Migraine is associated with altered processing of sensory stimuli