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All authors take responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation

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Tirzepatide is a dual GIP/GLP-1 receptor agonist - designed to act on both glucose-dependent insulinotropic polypeptide receptors and GLP-1 receptors

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Most recently, in a new structure of GLP-1R, a small molecule agonist, TT-OAD2, was shown to activate the receptor through binding of the helix IIECL1helix III region, revealing another ECD conformation 25

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