This includes increasing protein to 25-35% of daily calories, establishing structured meal timing, identifying trigger situations, and documenting baseline hunger patterns while still on medication
While the study did not include follow-up ICP measurements, the reduction in the Frisen grade and retinal nerve fiber layer (RNFL) thickness served as surrogate markers for ICP reduction
The p53(3KR) mutant, lacking acetylation due to lysine-to-arginine substitutions at three residues, decreases expression of SLC7A11 without affecting other p53 targets such as CDKN1A/p21 (involved in cell cycle progression) or BAX (involved in apoptosis)
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