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More recently, poly-agonist peptides have been developed to target multiple metabolic receptors simultaneously

Then came the SOUL trial , which demonstrated that oral semaglutide also reduces MACE by 14% , establishing that the route of administration does not blunt the cardiovascular protection

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A single dose of exenatide had no effect on blood flow velocity in the middle cerebral artery in elderly healthy volunteers: randomized, placebo-controlled, double-blind clinical trial