Implications for Health and Lifespan Improving healthspan is directly associated with a decrease in cellular senescence, which presents the prospect of increasing life expectancy rather than merely life expectancy
INDIRECT PATHWAYS AND EMERGING CONCEPTS Emerging concepts include the influence of the gut microbiota on patient responsiveness to SGLT-2is and GLP-1RAs, which may potentially allow patient selection based on gut microbiota patterns, targeting the microbiota to optimize patterns associated with therapeutic responsiveness and, in essence, a path toward precision and personalized medicine
Delayed gastric emptying a class effect may alter absorption of orally administered medicines, particularly those with a narrow therapeutic index such as digoxin or antiepileptics
However, research evidence does not support this concern at typical research doses: Multiple long-term animal studies (extending to 2+ years) have not demonstrated increased cancer incidence Research on IGF-1 signalling in cancer cells shows context-dependent effects (some cancer cells proliferate in response, while others actually undergo differentiation or apoptosis) The IGF-1 receptor is found on essentially every cell type, yet selective activation does not consistently promote malignancy That said, individuals with personal or family history of certain cancers (particularly hormone-sensitive cancers like prostate or breast cancer) should approach IGF-1 LR3 with appropriate caution and medical consultation if applicable
