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Oxygen-sensitive mitochondrial accumulation of cystathionine beta-synthase mediated by Lon protease

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The oxidized form (GSSG) has already "spent" its electron and cannot provide antioxidant protection until the body uses energy to recycle it back into the reduced state

1315 For example, elevated glucose concentrations activate the transcription factor carbohydrate response element-binding protein, which indirectly promotes GLP-1 secretion through regulation of target genes in intestinal L cells