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(The FDA has received more than 700 adverse event reports tied to compounded GLP-1s, but its not clear if the events were caused by the drugs.) The companies also see compounders as a threat to their obesity drug sales, which are estimated to balloon to $100 billion a year by 2030

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A separate 2024 study of 290 adults with obesity given oral semaglutide for three months found that free T3 decreased, free T4 rose slightly, and TSH fell during treatment