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Dehydration and Fluid Loss Dealing with dehydration and fluid loss from severe gastrointestinal side effects can also cause lower energy than normal

A fit and healthy 70-year-old with obesity-related complications may be an appropriate candidate, whereas a frail 68-year-old with multiple comorbidities and poor nutritional status may not benefit and could potentially experience harm

In addition, the role of GLP-1 RAs in special populations, such as during the periconceptional period, in geriatrics, or during religious fasting, further highlights the need for physicians to adapt these therapies to patient-specific needs

A patient with favorable FTO and GLP1R genotypes may experience more pronounced weight loss and metabolic improvements, potentially supporting greater cholesterol and triglyceride reductions