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The development of SGLT2 inhibitors and GLP-1RAs has reshaped the therapeutic landscape, demonstrating robust and glycemia-independent renoprotective benefits (Tomita et al., 2020)

In a methicillin-resistant Staphylococcus aureus (MRSA) infection model, mice treated with spermidine exhibited significantly improved survival rates and enhanced bacterial clearance, providing robust experimental evidence for spermidines potential application in treating infectious diseases and laying the groundwork for its clinical use as an immunomodulator (116)