doi: 10.1021/pr901188e 19
KPV exerts its primary anti-inflammatory activity through direct intracellular penetration of immune cells and intestinal epithelial cells, where it suppresses NF-B transcription factor activity the master regulator of pro-inflammatory cytokine gene expression through a receptor-independent intracellular mechanism, resulting in downstream reduction of IL-6, IL-8, TNF-, and related inflammatory mediators
gasseri , the bacteria were cultured in MRS liquid medium with or without different concentrations of QCHS (0, 5, 10, 50, 100, 250, 500, 1000, 2500, 5000 g/mL) for 24 h from the start of inoculation
After 50 days of continuous administration followed by 14 days of drug withdrawal, the total sperm motility of mice was almost 0, and a large number of abnormal eosinophilic spermatogenic cells appeared in the testis