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Response: We acknowledge commenters' concerns on the proposed 340B accelerated offset

Diabetologia (2016) 59:258893

Some studies have reported GLP-1R expression identified through immunohistochemistry in human liver tissue or liver cell lines, 43,44 but RNA sequencing has not detected GLP-1R in human liver tissue, including the non-parenchymal Kupffer or stellate cells

Yes, rapid initial weight loss often correlates with a greater initial metabolic shift, making the subsequent Metabolic Adaptation phase potentially more challenging to overcome effectively