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When used in combination with other medical treatments, melatonin has been shown to enhance the overall effectiveness of melasma therapies by reducing oxidative stress and inhibiting melanin production

Key mechanisms: Stimulates collagen and elastin synthesis in fibroblasts at concentrations as low as 1 nanomolar Modulates expression of at least 4,000 genes, including pathways governing DNA repair and antioxidant defence Attracts immune and endothelial cells to sites of tissue injury Promotes angiogenesis (new blood vessel formation) essential to delivering the nutrient supply that skin remodelling requires The evidence: A foundational peer-reviewed study in BioMed Research International confirmed that GHK-Cu stimulates both collagen synthesis and breakdown simultaneously functioning not as a crude growth signal but as a regulator of the full extracellular matrix remodelling cycle