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Animals treated with kin-19 RNAi exhibited a gene expression profile characteristic of fasting-induced NHR-49 activation, including the differential regulation of established NHR-49 targets, acs-2 and fat-7 (Fig

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Unlike SGLT2 inhibitors, which carry a well-documented risk of genital fungal infections, GLP-1 drugs do not share this mechanism

For example, C16-carnitine (10 M) may impair mitochondrial function in rat ventricular myocytes by accelerating ROS production and increasing the probability of mitochondrial permeability transition pore (mPTP) opening, whereas low concentrations (1 and 5 M) of C16-carnitine lightly hyperpolarize the m but do not open the mPTP [293]