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[7] DPP-4 inhibitors (such as sitagliptin) provide modest glucose-lowering with minimal side effects, though less efficacy than GLP-1 agonists
reported that treatment of human islets with sitagliptin resulted in a sevenfold increase in islet active GLP-1 content (14), and similarly, in vitro treatment of human islets with linagliptin (114) and vildagliptin (115) has been shown to stabilize active GLP-1 in islet supernatants and protect non-diabetic human islets from experimentally induced beta-cell damage (114)
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