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About the Study Study Type : Prospective, single-arm study evaluating the off-label use of GLP-1 RAs Duration : 24 months Participants : 110 adults with upper or lower extremity lymphedema (ISL Stages II and III) Primary Objective : Assess improvements in quality of life using the Lymphedema Life Impact Scale (LLIS) Secondary Objectives : Measure changes in limb volume, bioimpedance, BMI, compression use, and incidence of cellulitis Participants will receive GLP-1 RA treatment for six months, with the medication prescribed and managed by their primary healthcare provider

GLP-1 therapy is administered via subcutaneous injection once a week

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